| Group | Club/Team Name | Team ID | Head Coach |
| L21 | Bluffton Rush Soccer Club - 01 Bluffton Rush 2010 Boys White |
03040-001AB2U-0016 | Michael Haughton |
| L22 | Coast FA - 01 Coast 10 Black |
03018-001AB2U-4577 | Nestor Chacon |
| L23 | Daniel Island SA DISA U12 Milan |
03030-001AB2U-0097 | Vladimir Henderson-Suite |
| L24 | Dorchester United SC - 01 Dorchester United SC - 01 - G12U |
03038-001RG2U-0016 | Todd Hamilton |
| L25 | Kickoff Soccer Academy - 01 KOSA 2010 Boys Yellow |
03033-001AB2U-0049 | Luis Bravo Alamilla |
| L26 | Mt. Pleasant SC - 01 MPRD Hurricanes U12B |
03007-001RB2U-0278 | Kristopher Andrews |
| L27 | South Carolina Surf Soccer Club SC Surf MP 10 Black |
03008-001AB2U-0240 | Max Correa |
| L28 | Southside Soccer Club Southside 10 Blue |
03012-001JB2U-0002 | Stephanie Moldenhauer |
| L29 | Walterboro SC - 01 WSC 10/11 Boys |
03020-001AB2U-0099 | Matthew Panza |